Differin Gel Acne Treatment contains adapalene, an Rx-strength acne-fighting retinoid that helps clear breakouts where they start (works deep into pores in 5 minutes), helps prevents new acne from forming, and as a result, can restore skin�s overall tone and texture. Adapalene is the first over-the-counter active ingredient for acne in more than 30 years. It clears acne with the power of an Rx without the prescription, prevents breakouts, blackheads, whiteheads, blemishes and clogged pores, and can be used to effectively treat acne, or maskne, caused by wearing face masks or facial coverings. When used as directed, you could start to see results in as little as 1 week, and when used every single day, Differin Gel can help reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories).
Product Dimensions : 1.69 x 2.8 x 7 inches; 1.59 ounces
Item model number : 0299.491040
Department : Beauty & Personal Care
UPC : 302994910403
Manufacturer : Galderma
ASIN : B07ZTN5N1V
Customer Reviews: 4.6 4.6 out of 5 stars (9,733) var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
TARGETS ACNE: Clear and prevent acne with the first FDA-approved prescription strength over-the-counter acne retinoid
CLEARS, TREATS & PREVENTS: Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
RX STRENGTH ACNE RETINOID: Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
DERMATOLOGIST RECOMMENDED: Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
REAL RESULTS: In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
THE CREATORS OF ADAPALENE: A Retinoid that Fights Acne
-34%
Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)
Original price was: $36.49.$23.97Current price is: $23.97.
0
People watching this product now!
Reviews
8 reviews for Differin Acne Treatment Gel, 90 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 45g Pump (Packaging May Vary)
Shop Woodmart
Prima –
Dependable Retinoid That Keeps Skin Clear and Balanced
I’ve used Differin Gel on and off for years, and it’s consistently dependable in helping keep my skin clear and breakout-free. It’s gentle enough for sensitive, acne-prone skin yet effective in preventing clogged pores and future breakouts. I also like using it as part of my anti-aging routine. it’s a great alternative to tretinoin on days when I want something a little milder but still effective.The texture absorbs well without irritation or dryness when used correctly, and it layers nicely under moisturizer. For a 90-day supply, the price is absolutely worth it considering how well it maintains skin clarity and smoothness. Differin remains one of those reliable, science-backed products I always keep in my rotation for long-term skin health and maintenance.
Sean Bozarth –
Effective Acne Treatment That Works Gently Over Time
I’ve been using Differin Acne Treatment Gel consistently, and it’s one of the most effective acne products I’ve tried, especially for long-term results. The 0.1% adapalene formula feels lightweight and spreads easily, and the pump packaging makes it simple to dispense the right amount without waste.What I appreciate most is how gentle it is compared to other retinoids. When I first started, I eased into it, and while there was some mild dryness, it was manageable and temporary. With regular use, my skin adjusted well, and I started noticing fewer breakouts and smoother texture overall. It doesn’t feel harsh or irritating when used properly, which is a big plus for sensitive or acne-prone skin.Over time, Differin has helped reduce clogged pores and the frequency of new breakouts. It’s not an overnight fix, but with patience and consistency, the results are real and noticeable. It layers well with moisturizer and doesn’t pill, making it easy to fit into a nighttime routine.Overall, this is a reliable, dermatologist-recommended acne treatment that delivers results without being overly aggressive. If you’re looking for a proven retinoid that works gradually and gently, Differin is a solid choice and well worth sticking with.
Brenda McCurdy –
This has really helped me with my acne!
I really like this for acne. I had to let my skin get used to Differin before I could use it every night. At first it really dried out my skin but I changed to only 1 time a week and changed to every other day and now it works out great! My Dermatologist suggested it for me and I found it on Amazon of course! Price was reasonable and I put it on my subscription which helps a lot. If you do have acne I definitely suggest you try this but only if you’re over 12 yrs old. Also, use moisturizer with it.
Sincerely Sherrell –
Life‑Changing Acne Treatment That Actually Works!
I’ve struggled with persistent breakouts for years, and the Differin Acne Treatment Gel (90 Day Supply, 0.1% Adapalene) has honestly been a game changer for my skin. This retinoid treatment delivers real results without the harsh irritation I’ve experienced with so many other products.✨ Cleared My Acne: After consistent use, my breakouts have significantly reduced. Even stubborn spots heal faster, and I’m seeing fewer new blemishes overall.🧴 Gentle Yet Effective: I was worried a retinoid gel would dry out my skin, but this formula feels lightweight and absorbs quickly. I experienced minimal peeling or irritation—just steady improvement.📆 Great Value: A 90‑day supply is generous and makes it easy to stay consistent, which is key with acne treatments. A little goes a long way, so the tube lasts!💡 Easy to Use: I apply it once a day at night after cleansing, and it layers beautifully under moisturizer without pilling.If you’re serious about clearing acne and improving skin texture, Differin is worth trying. It’s hands‑down one of the most effective over‑the‑counter acne treatments I’ve used! 🌟🧖♀️💧
Jon –
Works.
This does help with controlling breakouts and treating acne. Works great, I use this during the day and at night I switch to geologie pm for night.
Jodi Eppler –
Gentle Yet Effective Acne Treatment for Sensitive Skin
This is a topical facial treatment I continue to come back to time and time again. Differin Acne Treatment Gel is effective without being overly harsh or expensive, making it a great option for both sensitive, mature skin and teenage skin.It clears up blemishes quickly without over-drying or causing irritation—something that’s especially important as skin matures. At the same time, it works just as well for my teen, helping control breakouts without the redness or peeling common with stronger treatments. A reliable, dermatologist-trusted product that works across ages.
Samantha S. –
Great Product
I really like Defferin. Now that it’s over the counter, it’s game over. I have extremely sensitive skin, I can’t wear certain makeup or use certain brands because of how sensitive it is. I break out or get hives with this sensitivity. I also have combo skin, with acne mostly around my chin (hormonal) with occasional T zone pimples. I have been using this on my skin, with a moisturizer, as it’s drying, and my skin is clear. I use the moisturizer-defferin-moisturizer philosophy. My skin is even clear from hormonal acne. I use it very sparingly. A little goes a long way. It doesn’t smell like anything. If you do decide to use this on its own, it can be extremely drying. It’s clear in consistency, so I don’t notice any streakiness. It’s not oily either. The bottle is very effective at getting all the product out. Definitely recommend if you are battling with mild to medium breakouts. It also really helps with pore size. I have larger pores and it’s really shrunk the appearance of them.NOTE: If you go into the sun without sunscreen (or even with) it can make your skin more susceptible to sunburn. I did learn this the hard way.
James D. –
I used it only for 3 days and it dried my skin so much that I had red patches. Stopped using immediately